Put 100% of liquid samples or LC effluents into your ESI!
Same device makes highly sensitive MALDI crystals.
Same device dispenses blood, cells, non-touch near an MS!
Same device dispenses liquids non-touch into optical cells.
Same device does pipette/MS !
Same device is inexpensive and simple to use.
Applications. Shoot "drops" in a straight line like this ........ Why spray? Youtube clip 1 or 2
Dispense viscous liquids blood,cells,polymers, non-touch.
Fine crystals faster,cheaper than Labcyte's $400k Echo.
Dispense 384,N channels, 1 msec. Fastest in the world.
Fly nLs into,onto optical cells, mix in spectrophotometer for nanotitrations.
"Print" nLs,uLs,pLs from pipettes, syringes, LC's, chips, SPE's to targets,humans.
Apply to UPLC, electrophoresis, microscopy,crystallography, HDX, std and sample prep.
Use the Cool Wave to test the Beer's Law of Mass Spectrometry, short or long version.
We'll coauthor proposlas, teach students how to fly liquids: from "anything" to "anything!"
*Our nanoLiter Cool Wave dispenser allows you to launch or place, non-touch 100% of your liquid sample (as nanodroplets or nanoliter droplets, {pLs too}) into your ESI/MS or onto almost anything using our NEW patented devices! The same device yields excellent, homgeneous, deposits for high sensitivity MALDI, SIMS and DART with an average a factor of 20x increase in sentivity and major (3 to 20 X) increase in reproducibilty for proteins, peptides, synthetic polymers, explosives, drugs of abuse and more.
*Our Technology proves that you don't need an expensive funnel or a step if you can shoot drops in a straight line like this............... or like this _____.....______.... Also, our inexpensive device that can yield 100% sample transfer efficiency can save your MS (or other lab, project, dispensing or other platform) literally $380 to 480k compared to expensive, obsolete funnels or steps that start from the wrong electrostatic perspective, i.e. a spray.
* In addition our simple device can non-touch dispense viscous liquids (up to 1000 to 3000 cps) including whole human blood, serum, and other physiological fluids, viscous agents and other liquids (some glues,paints,polymers) for other dispensing applications.
*Other Apps include titrating and mixing liquids fired into optical or other cells. Our Cool Wave dispensers place or fire liquids at high speed so that 100% of your sample is shot, directed and optionally counted as descrete drops. This includes drop contents that may be cells/cell fragments, nanoparticles, serum, proteins, metals, whole blood, viscous agent liquids, slurries and more doing so at ambient, or any temperature or pH with optional patented,pending IBF sample treatment, i.e., filtration, SPE, LC or ULPC sample treatment or patented serially parallel derivatives thereof!
*The same nL dispenser can produce, homogensous nL deposits of whole blood for dried blood spot analysis. The same device is being tested at NIH for the characterization of bacteria by MALDI AND ESI, producing excellent homogenous crystals. Wisconsin used the device for single cell MALDI! MALDI, SIMS, and DART sensitivty has been shown in the peer review literature to be increased by literal factors of 10 to 100 x when nanoliter samples are compared to identical analysis of uL volumes of the same sample, a very counterintuitive but real set of obsevrations.
*America's greatest mass spectroscopist called our breakthrough IBF technology "great" and our ability to shoot cells/fragments into MS systems, "very exciting!" We agree.
Why, How and Where Nanoliters?
* IBF is a simple way to accurately manipulate liquids for many applications.
* IBF is covered by patents,hidden pending patents for liquid handling from syringes,pipettes,pumps,chips, SPE devices and for LC/MS and MS/MS and manufacturing of many types and other fluidic embodiments. IBF technology is available for license.
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