home     about us     technology    links/reviews     news     products

Nanoliter, with very rapid growth & with torrid technology is seeking development and investment partners in areas of  nanoliter syringes, nanoliter pipettes, nanoliter pumps, nanoliter polymers, and nanoliter instrument introduction.

ABOUT NANOLITER , LLC

Nanoliter is a Nevada based LLC with partners in the Bay Area, Southern and Mid-California, Florida and Pennsylvania. Nanoliter is growing rapidly with ongoing  collaborations in DC, St. Louis, California, Florida, Boston, Georgia and elsewhere. Nanoliter develops and sells  fluidic technology, components, related electronics, and related rights, as it offers integration services protected with a powerful IP wall. Nanoliter LLC is owned by Mr. Drew Sauter and Mr. Andrew D. Sauter III who co-founded the firm and who co-invented new devices like the nanoliter syringe, the nanoliter pipette, the nanoliter pump, parallel eK LC, unique sample introduction and liquid handling technologies and electronics and other IP.

Nanoliter's technology is dramatically improving MALDI analysis of polymers and it also offers labs and others a great way to save on expensive reagents as it reduces exposure and pollution. Nanoliter IBF tech is intelligent and extremely GREEN !

Background.

Nanoliter, evolved from our twenty five year consultancy in mass spectroscopy, numerics, analytical chemistry  and in related technology, IP and business development. That entity was sole source procured as an expert by six different branches of the federal government and by numerous corporations as diverse Lockheed, WMX, RTI, Sciex and Kraft Foods. Those services were based on Drew being involved in  many firsts in mass spectroscopy, analytical chemistry and numerics.

For example, Drew was the first to demonstate LC/MS/MS and HTS at the annual ASMS meeting in 1983 in Boston using Bob Finnigan's first TSQ (or MS/MS), the technology patented by Enke and Yost. He also published the first quantitative MS/MS (TSQ) paper in the peer review literature and managed early MS/MS R&D by UVA's Hunt and Shabanowitz. He also acquired some of the earliest funding for the inventor of ICP/MS, Sam Houk. That was after he developed and improved the first GC/MS methods for priority pollutants and QC protocols which is the core technology employed across many USA's federal environmental regulations for the last thirty years. These methods and QC practices are applied to test drinking water, identify hazardous wastes, hazardous waste sites and in air pollution work. In helping to construct the first database of pollutants in the USA's rivers identified by GC/MS (17 labs and 20,000 files in 1979) and that were employed to set water treatment standards in thhe USA, he coauthored papers on database building, signal processing and pattern recognition. (Aside: Drew also managed or performed 6, 7 and 8 figure MS contract R&D projects at RTI, DoD, LANL, Oak Ridge, Lockheed, Sciex, WMX and other organizations, mostly in the USA, and he has authored three successful business plans and uniquely published three mass spectrometry interlaboratory studies in the peer review literature..)

Subsequently, he acquired funding for what became PB/LC/MS. That project later independently spawn the first bench top LC/MS system which was licensed by Agilent and eventually purchased by Waters, that being their entry into the MS business. Drew, later worked for various major corporations, USDOJ and Los Alamos National Lab and others developing business plans, and developing numeric ways to study MS data for integrity and quality using exploratory and confirmatory multivariate statistical techniques, pattern recognition, graphics, the PC and other tools. 

Drew had always had an interest in quantitative MS. In fact, his paper on ionization cross sections has been cited in the peer review literature over 122 times to the present (Aside: That paper was used by Roussis in 1995 to develop a highly accurate approach to estimate molecular collisions cross sections.). Then in an informal collaboration with Affymax and Agilent in the 90's, he read over 600 papers studying electrospray ionization (ESI), the technology invented by Professor John Fenn for which he shared the 2002 Nobel Prize. Drew and his collaborators, Chakel, Fitch and others presented the first model that attempted to explain ESI in 1997 at Pittcon.

In studying ESI, Drew performed some experiments, and from that he came to invent and patent what has come to be known as induction based fludics (IBF). IBF uniquely employs electric fields to fly liquids to and from targets with extreme accuracy and precision at the lowest cost per channel, across the widest dynamic range of any technology on the planet. Applications that he invented and patented include: the first electrokinetic parallel LC; parallel SPE; parallel filtration; parallel dispensing; parallel instrument introduction and more including hybrid systems and serially parallel derivatives of the above. We believe that this technology, IBF, is the single most important "new" sample preparation technology on the planet as we can print with samples onto humans or other targets, into instruments and otherwise using even highly viscous liquids. IBF has massive applications in manufacturing of microarrays, electronics, medical devices and more. Drew is working to commercialize this IP and develop new technology in MS and sample preparation areas with devices like the nanoliter syringe, the nanoliter pipette or nanoliter pumps. To that end, Nanoliter has or is working with MDS Sciex, Spark Holland, DoD, major universities, cancer research centers, the US government and others.

As one measure of the power of IBF, just in the last year using our digital Nanoliter Cool-Wave System (Syringe) was shown by M. L. Gross et al to yield a 10x increase in MALDI protein analysis ( Bradykinin) sensitivity and a 5 x increase in reproducibility. This same technology also received an honorable mention for best new instrument at Pittcon 2007 and it was very well received at Asilomar where a key person involved in the 2002 Nobel Prize work said: " I like it," referring to IBF. We liked that.

Selected References.

LINK , A.D. Sauter, L.D. Betowski, B.N. Colby, T.R. Smith, and R.G. Beimer, “Fused Silica Capillary Column GC/MS Analysis for Priority Pollutants,” HRC&CC, August, 1981, 366-384. If you drank water in the USA during this period, THE approach to test for organics {VOA's and semiVOA's} we developed and demonstrated, of course, prior to the existence of off the shelf instruments. The first work, was actually accomplished at MRI in 1976.

 Another Related Link On .... Interlaboratory GC/MS Precision. In our original ASMS 1980 poster session we showed how to couple FSCC directly to the ion source of MS systems, and that has become the way GC and MS have been interfaced to this day, thirty years later.

A.D. Sauter, L.D. Betowski, and J.M. Ballard, “A Comparison of Response Factors for Triple and Single Stage Quadrupole Mass Spectrometers,” Anal. Chem. 1983, 55,116.

W.L. Fitch and A.D. Sauter, “Calculation of Relative Electron Impact Total Ionization Cross Sections for Organic Molecules,” Anal. Chem. 1983, 55, 832.

A.D. Sauter, et al, Analytical. Chemistry. 1986, 58, 1665.

A.D. Sauter, et al, “Perspectives on Data Integrity and Quality,” Environmental Lab, June, 1992, p. 25.

A. D. Sauter, W. Fitch, J. Chakel, A. Affel,  et al, "Approaches For Estimating ESI/MS/MS Relative Response,”  Pittcon 97, New Orleans, LA, March 1997.

A. D. Sauter and A. D. Sauter III, “Nanoliters Onto Media, Use Of Electric Induction,  American Laboratory, October, 2001.

A. D. Sauter and A. D. Sauter III, “ ‘Electric’ Zip Tips For MALDI And Other Applications,”  Journal of the Association of Laboratory Automation, May-June 2002.

A. D. Sauter, Sample/Standard Preparation: Manipulating Liquids With IBF. Course Book For Presentation at Pittcon, 2005/07.

A. D. Sauter and A. D. Sauter III, Introducing the Nanoliter Syringe, the Nanoliter Pipette and the Nanoliter Pump, Pittcon 2007, Chicago, Il, March 2007. System received an honorable mention for best new instrument.

A. D. Sauter et al, Launching & Directing Nanoliters To Diverse Targets With Electric Fields,  Induction Based Fluidics, poster session presented at ASMS 2007, Indianapolis, IN, June 2007.

 T. Tu, A. D. Sauter, Jr., Andrew D. Sauter III  and M.L. Gross, Improving Intensity and Sensitivity of MALDI Signals by Nanoliter Volume Spotting, poster session presented at ASMS 2007, Indianapolis, IN, June 2007, now in print.

************************************************************************

Some of our 2007 Press Releases

Nanoliter featured in Instrumenta.

************************************************************************

Summary

Nanoliter is actively seeking to license its technology and to identify corporate commercialization partners, as we develop new technology and new tools. We believe that this technology  will be in many labs, worldwide in a few years time, and perhaps in the home and the factory. If you are interested in nanoliter dispensing for YOUR application or for your dispensing or sample treatment platform, or for parallel LC/MS/MS with sample placement  for cancer detection, or in the patent pending Nanoliter, Microliter Syringe, or in parallel liquid introduction to non MS instruments, or for parallel sample placement onto or into things, or  for parallel SPE , or parallel filtration or for serially parallel derivatives thereof, call Drew Sauter.  He can be contacted at 702-896-5413,  asauter@aol.com or at nanoliter.com.

About Nanoliter's Drew Sauter

Nanoliter is co-owned by Drew Sauter who holds a BS and a MS degree in Chemistry from Duquesne and Marquette, respectively, and by Andrew D. Sauter III, EE, Santa Clara University.  Drew's perspective is that of one who has been fortunate to work with many experts as sited above that have actually successfully recognized, invented, introduced, and applied many new technologies/components in analytical chemistry in GC/MS, LC/MS, MS/MS and microfluidics for over thirty years. Drew is very fortunate to have a developing array of expert technical and business advisors that have extensive business acumen with deep technical knowledge and who hold numerous patents. Such extensive experience in basic and applied science and in business aspects of technology development and implementation are helping us evolve.