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NEWS Nanoliter seeks instrument company to participate LC/MALDI R&D project with major US gov't agency. We'll morph your dispenser into a LC MALDI device, in exchcange for funding of this project which will almost undoubtedly shed light on a major cancer type, based on already acquired data.
100% Guarantee increase in MALDI Sensitivity and Reproducibility, 10 to 100 and maybe 1000x. No joke!
New JASMS paper showing major improvement when using nanoliter deposition! " Improving the Signal Intensity of MALDI Mass Spectrometry by Using Nanoliter Spots Deposited by Induction Based Fluidics. Coauthors include: Tingting Tu; Andrew D. Sauter, Jr., Andrew D. Sauter III And M. L. Gross; of Washington Univ. in St. Louis. now on-line and in print this August. 100% Sweet Spot !?!
Download an ASMS 2008 handout.
Data just acquired at NIH shows a major increase of 100 in negative ion MALDI of very important proteins. Other data presented at ASMS showed 10 to 1000 times increase in proteins and polymer analysis sensitivity.
IBF can produce and count nanoliters. Fly nLs from syringes, even fly viscous liquids up! IBF can fly them in msec from LC columns to targets and effectively print MALDI plates fast.
IBF honorable mention: nL syringes best new technology, Pittcon 2007 & 2008. See Spark Holland's Alias (above) dispense nanoliters in milliseconds. .
Five year old dispenses nanoliters (really!) at Pittcon 2008. Beats MALDI sample prep experts worldwide in first attempt! HONORABLE MENTION FOR BEST NEW INSTRUMENT PITTCON 2008, SECOND YEAR IN A ROW! ASMS booth 88! See video of us dispensing nanoliters to MALDI plates, accompanied by Eric Clapton. Nanoliter establishes small manufacturing facilities in CA. Nanoliter seeks partner to build low cost parallel LC based on work conducted for largest LC/MS firm in the world.
The nL syringe, the nL platform.( Print MALDI Plates in seconds, literally.) & a new digital nanoliter syringe, 11/07. USF & Nanoliter submit paper showing ability to count & measure nanoliters to Analytical Chemistry, May 08. Paper accepted, JASMS,. showing that by using nLs, at least a 10x increase in MALDI sensitivity and reproducibility realized. International rights available for selected IBF technology. Millisecond nanoliters, 10x,100x increase insensitivity, and discrete pLs demonstrated. Nanoliter joins ASMS as corporate member. Nanoliter sample preparation is shown in general as preferred for MALDI sample preparation in Analy. Chem., 2008, 80,491-500. Nanoliter to present at Lab Automation, Tuesday, January 29, 2008, 1 to 3:00 PM. Stop by the booth to dispense nanoliters ! Nanoliter technology discussed December's Biophotonics International .(See page 58, Dec 2007 edition.). Milli-microsecond, single/parallel nanoliters demonstrated, 11/17/07. Fast and cool! Nanoliter awarded 3/4 stars from Germany's Kramer & Hoffman, tech IP website. Kuhl (mit da umlat)! Nanoliter ships Nanoliter Cool-Wave to NIH, DC. Very Cool!
Another device just born!
Nanoliter (9/07) with USF & the Moffitt Cancer Research Center proposes to bring IBF to biomarker R&D for NCI. Nanoliter installs (8/07) Nanoliter Cool Wave at Hitachi's Grass Valley, CA Facility. Cool! Nanoliter, USF's Professor Julie Harmon and Spark Holland's Rob Van der Knapp presented a well received poster at ASMS's annual Asilomar conference September 14,18 2007 on Molecular Diagnostics and Clinical Chemistry: "Nanoliter Sample Handling: MALDI, Parallel LC/MALDI, Drug Delivery and Patient Sampling With Induction Based Fluidics. Why The Nanoliter Regime Has Merit." Nanoliter, Dr. M. Johnson ( Duquesne U) & Dr. J. Harmon (USF) to present a 4 hour course at Pittcon 2008.
The nL syringe, the nL platform.( Print MALDI Plates in seconds, literally.) & a new digital nanoliter syringe, 11/07 & 6/08.
Nanoliter Cool Wave System installed at Professor J. Harmon's lab at the University of South Florida, 8/2/07. Cool! Nanoliter teams w/ polymer experts: MALDI sample prep apps. See exciting new data and announcement @ ASMS. Nanoliter agrees to terms of new licensing deal. Details to be announced at ASMS. Nanoliter Wave installed at National Mass Spectrometry Center, NIH's MS facilty at Washington University, St. Louis. Significant increase in MALDI protein S/N results observed. Watch for ASMS presentations. Read other ASMS 2007 ABSTRACT. MS Sample Preparation And Induction Based Fludics, Our Other ASMS Abstract with Washington University. and Spark Holland B.V. READ ASMS 2007 ABSTRACT: Improving Intensity and Sensitivity of MALDI Signals by Using Nanoliter Volume Spots, Tingting Tu1, A. D. Sauter2, Michael L. Gross1, 1. Washington University in Saint Louis and 2. Nanoliter. Nanoliter featured in Instrumenta. Nanoliter in Smalltimes, Nanoliter featured in Separations Now. Nanoliter to present posters with Washington University at ASMS Annual Meeting. Nanoliter receives Honorable Mention for best new instrument at Pittcon 2007!!!!!!!! Nanoliter syringe to be introduced at Pittcon2007. See Press Release, Course & Sauter's presentations. Major MS group and Nanoliter Syringe shows 10X increase in MALDI S/N. Watch for ASMS posters. nL begins collaboration with Washington University, 1/2007. nL files for new US and foreign IP. nL poster at Lab Automation 2007. nL Syringe Introduced, 1/11/06. See press releases. Nanoliter to have February 2007 American Lab Article & Exhibit At Pittcon 2007. Nanoliter to present three papers at Pittcon 2007: How To Make MALDI Plates Fast; Introducing The Nanoliter/Microliter Syringe/Pipette and The Why & How Of Induction Based Fluidics, at the Invited Session:"Drops." Meet us at the Sunday afternoon/night poster session for Nanoliter Discussions and liter sized beverages. Nanoliter to again offer our course at Pittcon2007. Nanoliter to collaborate with NIH on MS and sample prep applications using IBF. Nanoliter spoke at Nevada Cancer Institute, 6/06. Nanoliter signs letter of collaboration with Nevada Cancer Institute, 5/06 Nanoliter also signs letter of collaboration with Nevada Proteomics Center, 5/06. Nanoliter enters licensing negotiations with 1/2 largest MS firms in the world. See WSJ 12/31/06 Article on Cancer/Disease Diagnostics. that our unique patented nL technology feeds! Nanoliter to teach at Pittcon 2006 on parallel LC/MS and IBF based depositions. Nanoliter files new patent to covering nanoliter and microliter aspiration, 8/05 ! Learn about it at our course coming to Duquesne University. See immediately below. Nanoliter to present a short course on Nanoliter dispensing, printing with LC columns and other applications of IBF at Duquesne University October 4 and 5 th. Nanoliter's introduction accepted for Pittcon 2006. Nanoliter presented at Pittsburgh Life Science Greenhouse. Nanoliter to presented a poster at Labautomation:"The Nanoliter, Microliter Syringe That Can Dispense Picoliters." See number WP074. Did you know that using low volumes of reagents can make MALDI TOF 1000 x more sensitive? Guess who makes and accurately places Nanoliters & Picoliters? Your MS manufacturing firm or MS lab can license that patented tech that can combine both ESI and MALDI technology into one platform, as it greatly increases sensitivity. Nanoliter gets headlines in September Instrumenta. Press Release: MDS Sciex and Nanoliter Collaborate On R&D Contact. Nanoliter a macro/microfludics startup with offices in Henderson,NV , and affiliates in Carlsbad,CA and Pittsburgh, PA signed an R&D agreement with MDS Sciex, of Concord, Ontario Canada. MDS Sciex is a major supplier of Scientific instrumentation, expendables and a provider of testing services. MDS Sciex offers key technology in the field of proteomics, genomics and other areas including drug discovery, diagnostics, homeland security and environmental areas. Nanoliter's technology discussed at nanoliter.com revolves around patented and patent pending macro and mircrofluidics technology termed Induction Based Fluidics."
Introductory short course accepted for presentation at Pittcon 2005. " How To Dispense, Aspirate & Manipulate Picoliters and Nanoliters In Your Lab Simply,Inexpensively. "New course is to be offered on Induction Based Fluidics (IBF) :"Flying Nanoliters!" The course will be co-presented with Dr. Mitch Johnson of Duquesne University. TBA.
Nanoliter Finalizes Model of IBF, July 2004. The Nanoliter, Microliter Syringe" Presented At The National Environmental Monitoring Conf., July 20, 2004, Wyndham Hotel in DC. April 2004, Government Co-bids Nanoliter In Unique Seven Figure Project. New Patents Pending. MALDI providing exciting cancer & disease diagnostics capabilities, and Nanoliter's patented technology is the only one in the USA that does parallel LC and sample placement concurrently for MALDI applications. You can purchase an evaluation license and consulting for this technology, now and begin to effectively compete with Agilent and other major MS manufacturers, now based on our years of experience, inventing IBF.
A Bit Older "News" Nanoliter selected by NIST and other judges. Presented at Nanocommerce2003 in Chicago. Nanoliter interviewed by New York Time's Barnaby Feder.
Novartis' Ansgar Broch et al, published paper on parallel dispensing and parallel LC, May 2003, (and in two interviews to technical press) does NOT reference Nanoliter's patent first filed two year earlier, and articles despite years of numerous perfectly documented nanoliter.com visits by Novartis group! Verifies IBF value. Sez little about integrity.
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