NEW !!!
Disruptive Mass Spec, Analytical Liquid Handling Tech
*Our nanoLiter Cool Wave dispenser allows you to launch or place, non-touch 100% of your liquid sample into your ESI/MS or onto almost anything using our NEW patented tech/devices! The same device yields excellent, homgeneous, deposits for high sensitivity MALDI, SIMS and DART with an average a factor of 20x increase in sentivity and major (3 to 20 X) increase in reproducibilty for proteins, peptides, synthetic polymers, explosives, drugs of abuse and more.
*Our Technology proves that you don't need an expensive funnel or a step if you can shoot drops in a straight line like this............... Also, our inexpensive device that can yield 100% sample transfer efficiency can save your MS (or other lab, project, dispensing or other platform) literally $380 to 480k compared to expensive, obsolete funnels or steps that start from the wrong electrostatic perspective, i.e. a spray.
* In addition our simple device can non-touch dispense viscous liquids including whole human blood, serum, and other physiological fluids, viscous agents and other liquids (some glues and paints) for other dispensing applications. (See our Pittcon 2012 Course below.)
*Other Apps include titrating and mixing liquids fired into optical or other cells. Our Cool Wave dispensers place or fire liquids at high speed so that 100% of your sample is shot, directed and optionally counted as descrete drops. This includes drop contents that may be cells/cell fragments, nanoparticles, serum, proteins, metals, whole blood, viscous agent liquids, slurries and more doing so at ambient, or any temperature or pH with optional patented,pending IBF sample treatment, i.e., filtration, SPE, LC or ULPC sample treatment or patented serially parallel derivatives thereof!
*The same nL dispenser can produce, homogensous nL deposits of whole blood for dried blood spot analysis. The same device is being tested at NIH for the characterization of bacteria by MALDI, producing excellent homogenous crystals. Wisconsin used the device for single cell MALDI! MALDI, SIMS, DART (and DESI?) sensitivty has been shown in the peer review literature to be increased by literal factors of 10 to 100 x when nanoliter samples are compared to identical uL volumes, a very counterintuitive but real set of obsevrations.
*America's greatest mass specctorscopist called our breakthrough IBF technology "great" and our ability to shoot cells/fragments into MS systems, "exciting!" We agree.
How Nanoliters?
Nanoliter devices use Induction Based Fluidics, (IBF) to transport
and optionally dispense, treat, purify or chromatograph liquids. In IBF,
liquids are charged which launches them to targets of all types (e.g., MALDI
plates, humans, microscope slides, TLC or microtiter plates, food, evidence, IR and other spectroscopy cells, DART's, DESI's or MS's). The liquid
drops fly directed to locales where they can be measured on arrival, like ions in mass spectrometers. IBF is a new, simple way to transport and treat liquids
for many applications invented by Drew Sauter in 1996.
Why Nanoliters?
By using nLs via IBF one dramatically
reduces reagent costs, waste disposal costs and human exposure by
orders of magnitude. Also, one is empowered to do
new liquid handling tasks. IBF is a simple and green technology
that every lab in the world can afford and implement, rapidly.
Where Nanoliters?
* Shoot 100% of nL samples (of even viscous liquids) into your ESI now!
* Improve MALDI, SIMS and DART sensitivity 10-100x,LIERALLY,using nLs!
* Improve MALDI, SIMS and DART precision 3x to 20x, LIERALLY,using nLs!
* See (peer review lit.)by Washington U, NIST, NIH, Army, USF, JEOL, Wisconsin, others.
* Dispense nLs of Whole blood for homogenous dried blood Spot analysis for improved MS!
* Perform single cell MALDI, HDX in exciting new ways.
* Determine IMS protein cross sections at in vivo conditions.
* nLs improves SIMS sensitivity for explosives, drugs by 100 to 1000 per NIST!
* WIth IBF one can also........
* Dispense 96,384,1536 channels in 1 millisecond, the fastest in the world!
* Perform/dispense via highly parallel SPE, LC UPLC and tissue MALDI.
* Dispense nLs for nanotitrations, TLC, electrophoresis, Raman, IR, spectroscopy.
* Prepare samplea for MS in proteomics, genomics (DNA/RNA sample prep).
* Prepare samples for defense applications that use viscous liuqids.
* Cool human beings using IBF in garments via 12/009,791,
* Manufacturing: unique charged polymers,solids,consumer/other products, food, drugs.
* Research: optics or tissue gluing, dental anethetics dispensing, more!
* IBF is a simple, exciting way to manipulate liquids that can benefit chemist and others !
Our Pittcon 2012 Course: 100% Liquid Sample MS Introduction !!! See video of 100% of nanoliter drops flown into an ESI/MS. See nLs flown into levitated uL drops. Dispense nanoliters non-touch to MALDI and other targets.
Nanoliter Application Pics
We manufacture scientific equipment for non-touch, low volume liquid handling, treatment and sample introduction for mass spetroscopy, dried blood spot, MALDI and many other applications. Our technology can launch any liquid and some solids to "any" target. Our nanoliter Cool Wave dispenser can help you perform low volume,
non-contact, liquid handling tasks of many types using liquids of all kinds, even viscous liquids like human fluids, agents, cells, glues even paint and more. We also OEM flutronics, for instruments like dispensers, LC's and MS integrated. for fast and HTS applications.
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